suramin natural alternative suramin natural alternative

8. Suramin is a polysulfonated naphthylamine that is a primary agent in the treatment of African trypanosomiasis (African sleeping sickness) caused by Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense. We administered suramin, an anti-parasitic drug and reverse transcriptase inhibitor, to 15 patients with metastatic cancer. The richest sources of life-giving suramin today are conifers growing in ecologically clean regions of Siberia. 3 (2006): 899-906, 18.https://pubchem.ncbi.nlm.nih.gov/compound/Suramin-sodium. I have heard of a study at UCSD using Suramin to treat autism. "Suramin in the treatment of AIDS: mechanism of action. Now, a new study reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19. Further investigation of the herb reveals a study (Smith . (3) This study also says suramin doesn't work well on p2x4. Yes, it can certainly be found naturally. Ivermectin The use of ivermectin for COVID-19 has been controversial. 5. Suramin does not distribute well into cerebral spinal fluid and its concentration in the tissues is equivalently lower than its concentration in the plasma. The more stress, the more eATP is released. Suramin contains six aromatic systems four benzene rings, sandwiched by a pair of naphthalene moieties plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. UC San Diego Health, May 26, 2017, "Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy", "Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial", "Q and A - Suramin and Autism | UC San Diego Health", "Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases", https://en.wikipedia.org/w/index.php?title=Suramin&oldid=1126333005, Antrypol, 309 Fourneau, Bayer 205, others, This page was last edited on 8 December 2022, at 20:02. Dr. Naviaux frequently says, Our work is not about suramin, or any other single drug. I think thats an old wives tale. Nattokinase (proteolytic enzyme) has a history of being used to, Giant Hyssop or Horsemint (Agastache urtifolia), Wheatgrass and Wheatgrass Juice (the young blades). Taken together, the results show that sgp130 may exert an anti-inflammatory effect on microglia and neurons by inhibiting IL-6 binding. Whatever you do DO NOT use radiata pine needles, they are toxic. Salgado-Benvindo, C. et al. & Naviaux, R.K. Optical phenotyping of human mitochondria in a biocavity laser. [23], Suramin has been studied in a mouse model of autism and in a small phase I/II human trial. Ive seen some dandelions in a vegetable patch that were so big I could hardly believe how big they were. Suramin is a secondary agent in treatment of Onchocerciasis (river blindness), but because of its toxicity, it is rarely used. Could you please attach links if possible. Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately . An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many chronic inflammatory conditions. "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer. Find many great new & used options and get the best deals for PINE NEEDLE TEA 70GM PINUS SILVESTRIS VITAMIN A C ANTIVIRAL ANTIOXIDANT SURAMIN at the best online prices at eBay! Suramin was first synthesized by Bayer chemists in Germany in 1916. The chemical structure of suramin was kept secret by Bayer for commercial and strategic reasons, but it was elucidated and published in 1924 by Ernest Fourneau and his team at the Pasteur Institute. ! 17 (1987): 4694-4698. so i do wonder what the one is behind Suramin. We strongly caution against the unauthorized use of suramin.1Homeopathic use of suramin is also illegal and untested. More Powerful Immune System Boosters By Using Essential Oils! Jacques Update:Facebook and social media platforms are cracking down on Conservative/holistic health content. Graded amounts of extracellular ATP (eATP) are released from cells in proportion to stress. To evaluate the localization of this presumed alcohol binding site, the effect of the intracellular application of ethanol was studied on the inhibition of ATP-activated current by extracellularly applied ethanol. "Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines." readily accessible. [2], It is unknown whether it is safe for the baby when a woman takes it while breastfeeding. If you dont like something one way, do something else with it until it becomes acceptable. http://www.fedup.com.au, Dr Judy explicitly says that pine needle tea will NOT act as anecdote, in fact, it can be toxic and has similar properties to terpentine. Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. (PDF). Of-course its going to react. Pine needle tea (obviously nothing poisonous as most pine nuts (from all pine cones ) are edible but some are poisonous she was just covering her ass so to speak ppl have been makin this kinda tea for ages it has high vitamin c and has been used against scurvy for Mariners for 1000s of years, Do you know if the dandylion, star anise, fennel or pine needles have to be in tea or heated to release the suramin? Suramin may cause serious side effects. New drugs to inhibit eATP release by regulating pannexin channels are being developed. 2) Blocks Il-6 activity and binding to Il-6 receptor in cancer cells, https://www.autismweb.com/forum/viewtopic.php?t=30356&start=20, http://joe.endocrinology-journals.org/content/202/1/141.full.PDF. If you have any healthcare-related concerns, please call or see your physician or other qualified healthcare provider. The Journal of clinical investigation 90, no. . Xu, H. Eric, Wanchao Yin, Xiaodong Luan, Zhihai Li, Leike Zhang, Ziwei Zhou, Minqi Gao et al. "After the single dose, it was almost like a roadblock had been released," he said. 22. All vaccine people die . I was reading just yesterday about the Douglas Fir pine tree. Do you think that Rheum Palmatum is the richest plant? . The intracellular application of 100 mM ethanol did not affect the inhibition of current by 100 mM extracellular ethanol, suggesting that the alcohol inhibition of ATP-gated ion channel function involves the extracellular domain of the receptor. 1 (1987): 143-148. Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately. This compound is known to inhibit the binding of growth factors (eg, epidermal growth factor [EGF], platelet-derived growth factor [PDGF], tumor growth factor-beta [TGF-beta]) to their receptors and thus antagonize the ability of these factors to stimulate growth of tumor . "Studies on antitumor effects of pine needles, Pinus densiflora Sieb. Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. northwestern Africa and North America, is known . Sent in accordance with our Privacy Policy. The Naviaux Lab discovered that the unique properties of suramin made it the first in a new class of drugs that could be used to test the cell danger response (CDR) hypothesis for the origin and treatment of autism spectrum disorder (ASD). It is not found in pine needles and cannot be found in any herbal teas. "Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines. 24 (2020): 8331-8347. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. Journal of ethnopharmacology 35, no. Alcohol, well Ethanol, is not a p2x antagonist. This site is NOT intended to be a substitute for a healthcare providers consultation: NEVER DISREGARD MEDICAL ADVICE OR DELAY IN SEEKING IT BECAUSE OF SOMETHING YOU HAVE SEEN ON THIS SITE. Dr. Jennifer Danials Turpentine and sugar was a bit of a story about a Grand Mother had done for years. There is a lot of research available on the internet about this. Being jabbed with strange substances and experiencing shedding from those individuals has become a reality in this world we live in. Research is already being hurriedly done in that direction in the hope that many lives can be saved and much severe illness avoided. (2020). But, I would research it to the uttermost if I were you! [4], Suramin causes a fair number of side effects. They do change our DNA in the sense that they take it back to how it was when we were a baby. Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. Our bodies are built in such a way they can withstand being treated badly for a time, but it doesnt go on forever. Ren, P., Zou, G., Bailly, B., Xu, S., Zeng, M., Chen, X., Shen, L., Zhang, Y., Guillon, P., Arenzana-Seisdedos, F., et al. "Antiproliferative effects of suramin on lymphoid cells." Maca Root 8050mg Per Caps, 4 Months' Supply Supports Reproductive Health Natural. Antimicrob Agents Chemother 64(2020). Before going, I would want to ascertain she knows about this and could help you with the right dosage. Kudzu is one although it is not as potent. Press question mark to learn the rest of the keyboard shortcuts. It is a symmetric molecule in the center of which lies a urea (NHCONH) functional group. Suramin does not cross the bloo Treatment of late-stage human African trypanosomiasis is complicated by the presence of trypanosomes within the central nervous system (CNS). et Zucc. No Carter, not really. These people invite evil spirits to come into them and tell the HS He must depart! That our professionals and decision-makers have continued to allow this sham to . I took some weight recently, and noticed signs of having more estrogens Kudzu is one of the three plants that herbalist Buhner proposes for treating acute symptoms of "neuro-lyme" (and co-infections like Bartonella) - described as a sort of brain inflammation . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143661/, https://news.ycombinator.com/item?id=14458230. There was some discussion on Phoenix rising about alternatives but it all got a bit confusing for me. Healths Harmony Black Seed Oil Supplement - 120 Softgel Capsules. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. P2X receptors are sensitized by extracellular pH, the most extreme example being the P2X2 subtype where responses to ATP are potentiated under acidic conditions and inhibited under alkaline conditions; pH changes as small as 0.03 units affect the size of the responses (153). Kudzu has been shown to be an agonist of the P2X7 receptor (. The Neem's active substance, azadirachtin, 51 a tetranortriterpenoid plant limonoid, is a potent insect feeding deterrent and, if consumed, 52 causes . HUGE! De Clercq, Erik. Im so thankful that we are entering into a whole new era. We were lucky that suramin is a non-selective inhibitor of most of the known types of purinergic receptors. It loves the cold, the colder the better. We use cookies to ensure that we give you the best experience on our website. They are SO strict with raw over here. Just a point of clarification. ", 9. Thanks for being part of this journey with me. Jason Shurka was interviewing Dr Judy Mikovits PhD., and he asked the leading question: Do you know of any way, to heal oneself from the injuries from the current injection? [11], The molecular formula of suramin is C51H40N6O23S6. The N/W/O and all their minions. I'm fascinated and excited by this new research on cell danger response (CDR): Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial abstract and the ramifications for autism as well as anxiety and other chronic health conditions. [3] It is given by injection into a vein. I have a 21 year old son with autism "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR2B cells. A lawn treated with Roundup would also have no grass, as well as no dandelions, no anything. Shared from the research of: Joseph Mercado Article Author: Mike Adams Content Contributor: Natural News Blog Post #1174. 6. Suramin inhibits chikungunya virus replication through multiple mechanisms. Example segmentations of whole T . He uses the root only. I always come back to the analogy of a car. Personally, 40mg of Emodin a day for the past three weeks has not produced great results. I would have known that with a bit more thought. Journal of Clinical Oncology 7, no. 5. Kudzu is POSSIBLY SAFE for most people when taken by mouth appropriately for up to 4 months or when injected intravenously (by IV) for up to 20 days. Consult your own doctor. Ethanol has been found to inhibit ATP-gated ion channel function [aka p2x family afai] by shifting the agonist concentration-response curve to the right in a parallel manner, increasing the EC50 without affecting Emax of this curve. Here he talks about suramin, which Dr Judy mentioned. Green tea research shows an amelioration of behavioral aberrations by a daily intake dose of the extract; doses range from 75 to 300 mg/kg after postnatal day 14 up to day 40 in animals with . Its interesting whats going on first she says one thing and then another. [17]:378379[18], It is also used as a research reagent to inhibit the activation of heterotrimeric G proteins in a variety of GPCRs with varying potency. Or can you eat them raw or just cooked? by Kim Molisani January 2, 2022. 4. [2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. Cat's Claw. Suramin is 20 or more times as powerful as remdesivir, which is the only currently approved anti-COVID-19 drug. i just emailed a well known ME/CFS doctor i know (who wishes to remain anonymous) with the names of the two herbs/supplements mentioned at the top of this thread, and he said: "I have talked with every prominent herbalist I know to see if there is a similar substance out there, and so far, nothing.". You quoted Rheum Palmatum, but many other plants contain Emodin. Theres only one way to fight back and thats by joining my FREE newsletter. One important way that stress-triggered eATP is released occurs through pannexin 1 containing channels in the cell membrane. As her life is hounded by the authorities, Im guessing maybe she has had to back-peddle for the sake of her life. It is still early to say but maybe this will enter the top three interventions. $18.50. Many generations of locals strengthen their immunity with the help of natural teas from: Pine tree cones. All rights reserved / Site by, Post-treatment Lyme disease syndrome (PTLDS), Post-coccidiomycosis (Valley fever) chronic fatigue syndrome, Treatment-Resistant Major Depressive Disorder with suicidal ideation, NARP, Leigh, and other Primary Mitochondrial Diseases, Post-chemotherapy cognitive impairment, fragility, and accelerated aging symptoms, Chronic pain syndromes in children and adults, Drug addiction recovery therapy, e.g., opioid addiction with hyperkatifeia, Treatment-resistant, post-COVID long-haulers with multisystem chronic fatigue syndrome, Severe Obsessive-Compulsive Disorder (OCD), Pediatric acute-onset neuropsychiatric syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), As an additive in organ transplant media to improve organ survival, and decrease inflammation and rejection, Subacute-chronic traumatic brain injury (TBI), Postural orthostatic tachycardia syndrome (POTS)/Dysautonomia. I was desperate, and I gave her one capsule, 150mg, of Sytrinol. ", 10.Kartnig, Theodor, Franz Still, and Franz Reinthaler. 4 (1993): 701-710. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet. Having said that, we can do a lot more about it than simply sitting around and waiting to see who is harmed or dies. The purpose of this website is to promote broad consumer understanding and knowledge of various health topics. Direct TNF inhibition through identification of potent small . Usted recibir 1 2 correos electrnicos al mes (incluyendo los regalos de temporada!) Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. You can alsofind me onInstagram,Truth Social(a new free-speech conservative channel), MeWe andTelegram. Two hours later, wanted to do class with me and did her toughest one, reading. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Various routes to these compounds have been developed, including starting from separate naphthalene structures and building towards an eventual unification by formation of the urea[13][14] or starting with a urea and appending successive groups. It happened with the first a few days and soon I realized he started to sleep very well without Melatonin. With this blockade the GDP will not release from the G subunit so it can not be replaced by a GTP and become activated. Everything from high blood pressure, to psychological trauma, chemotherapy, surgery, toxin or pesticide exposure, stroke or heart attacks cause eATP to be released. [1] Specifically, it is used for treatment of first-stage African trypanosomiasis caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense without involvement of central nervous system. Of-course it helps towards keeping my website going. 17 (1986): 6440-6444. Ethanol was found to decrease the time-constant of deactivation of ATP-gated ion channels without affecting the time-constant of activation, indicating that ethanol inhibits the function of these receptors by an allosteric decrease in the affinity of the agonist binding site.