Poly = many and chromasia = color. The corpuscular defect may appear if it is inherited from either parent (it is caused by a dominant gene). These are made in your bone marrow, where they grow for about 7 days before they are released into your bloodstream. Pseudostrabismus Pictures, Test, Symptoms, Causes, Polycoria Pictures, Symptoms, Causes, Treatment. Small red blood cells poorly filled with hemoglobin are characteristic of a hereditary disorder of hemoglobin formation, thalassemia, that is common among Mediterranean peoples and is discussed below. Individual sensitivity is of several kinds. To prevent iron deficiency anemia in infants, feed your baby breast milk or iron-fortified formula for the first year. Iron is derived from the diet and absorbed in the intestinal tract. The term used to indicate a normal color or central pallor (i.e., normal hemoglobin content) is normochromic, Disseminated intra-vascular coagulopathy (DIC), Thrombotic Thrombocytopenia purpura (TTP). Both can lead to polychromasia on blood smear results. An impaired formation of alpha-chains leads to an overage of beta-chains. Red cells metabolize glucose by breaking it down to lactic acid either via an anaerobic (oxygenless) pathway or by oxidation through a pathway called the pentose phosphate pathway. 6 Principles of clinical oncology. While polychromasia itself isnt a condition, it can be caused by an underlying blood disorder. A malfunction of the abnormal hemoglobin may result in erythrocythemia, or overproduction of red cells. They lack the central pale area due to their spherical shape. So send us the full report of your CBC and we can explain things to you better. Fortunately, most variant hemoglobins are not sufficiently affected to alter their function, and therefore no observable illness occurs. Polychromasia is a disorder where there is an abnormally high number of immature red blood cells found in the bloodstream as a result of being prematurely released from the bone marrow during blood formation (poly- refers to many, and -chromasia means color. Most defects have to do with production and processing of the RNA from the -gene; in -thalassemia, by contrast, the gene itself is deleted. This results in a bluish colour of the skin and mucous membranes (cyanosis). Pappenheimer Bodies: are intracellular inorganic iron-containing granules that may be ob-served on Wrights stained peripheral blood smears. Common causes of iron deficiency are excessive menstrual loss in women and bleeding peptic ulcer in men. To improve the chances that your body will absorb the iron in the tablets, you may be instructed to: Iron supplements can cause constipation, so your doctor may also recommend a stool softener. With the exception of iron deficiency and thalassemia, hypochromic microcytic anemia is rare. https://www.ncbi.nlm.nih.gov/pubmed/1578956/ https://www.ncbi.nlm.nih.gov/pubmed/1578956/. Hemolytic anemia can also result as the consequence of an environment hostile to the red cell. Reduced platelets b. The three types of anisocytosis are: Anisocytosis with microcytosis - The red blood cells are unusually small in size. Basophilic Stippling: is the term used to indicate the presence of irregular basophilic granules in the cytoplasm of erythrocytes. This finding may occur in the context of haemolysis, though may also be seen during recovery following . About 1% of ovalocytes are found in a normal complete blood count. A different hemoglobin (Hb F) is present in fetal life and possesses a pair of the same -chains as does Hb A, but the second set contains gamma- (-) chains. Your red blood cells are the cells in your blood that carry oxygen to the rest of your body. Thanks to improved treatments, people with PNH now have near-standard life expectancy. Symptoms of paroxysmal nocturnal hemoglobinuria include: If you have any of these symptoms, your doctor will likely want to run some blood tests to determine if you have any of the associated underlying conditions. Your doctor may recommend over-the-counter iron tablets to replenish the iron stores in your body. 1+ polychromasia if: a. Radiation therapy is an important treatment option for cancer. An insufficient centrifugation . Sickle cells (drepanocyes): are interchangeable terms used to indicate sickle-like forms of erythrocytes (crescent-shaped, irregular spines, filaments, holly-leaf appearance) noted when RBC containing HbS are subjected to reduction in oxygen tension or pH. Such anemias may be severe but often can be controlled by the administration of adrenocorticosteroids (which interfere with the destructive process) and treatment of the underlying disease, if one is present. Anisocytosis: is a generic term used to indicate variation in shape of erythrocytes (e.g. Hypochromia refers to a reduction in the intensity of red blood cell colour. Any of the parasitic infection like hookworms can also lead to hypochromic anemia. In such cases, polychromasia becomes a side effect of the treatment rather than a sign of the disease. It means you have premature RBCs in your blood. As soon as the red blood cells are developed properly the bone marrow adds the cells to the blood stream, but in case of Polychromasia immature blood . 3-5 polychromatc cells are found per microscopic feld c. more than fve polychromatc . The diseases which cause increased formation of RBCs or the diseases in which the function of bone marrow is damaged can lead to finding of polychromasia. }); Iron deficiency anemia signs and symptoms, Chest pain, fast heartbeat or shortness of breath, Unusual cravings for non-nutritive substances, such as ice, dirt or starch, Poor appetite, especially in infants and children with iron deficiency anemia, Dark green leafy vegetables, such as spinach, Dried fruit, such as raisins and apricots, Iron-fortified cereals, breads and pastas, Medications, such as oral contraceptives to lighten heavy menstrual flow, Antibiotics and other medications to treat peptic ulcers, Surgery to remove a bleeding polyp, a tumor or a fibroid, Hammadah M, Brennan ML, Wu Y, Hazen SL, Tang WH. Polychromasia is a lab finding associated with multiple diseases. Since the first characterization of the nature of Hb S by American chemist Linus Pauling and his associates in 1949, more than 100 variant hemoglobins have been identified. Iron is the main component of hemoglobin and is the prime . ). Pneumobilia Pain - Symptoms, Causes, Treatment, Ul Blepharochalasis - Pictures, Meaning, Symptoms, Ca Hypergonadism - Pictures, Symptoms, Causes, Treatment, Retrognathia - Pictures, Symptoms, Causes, Treatment, Pseudoparkinsonism - Symptoms, Causes, Treatment, Hypermetabolism - Symptoms, Causes, Treatment, Iron deficiency anemia (due to iron deficiency on red blood cells), Sideroblastic anemia (it can be inherited due to gene mutation or can be acquired. They are composed of, Author: John Lazarchick Inheritance of deficiency of a pair of genes from both parents results in intrauterine fetal death or severe disease of the newborn. Increased MCHC c. Increased MCV d. Decreased RDW, 1. Under the name of chlorosis, this type of anemia was mentioned in popular literature and depicted in paintings, especially those of the Dutch masters, until the 20th century. Parasitic Infection. The Polychromasia is a type of condition in which the red blood cells inside the body start turn grayish blue in color. This condition occurs because of increased rate of speed of RBC production, or because of faulty RBC factory that is bone marrow. Hypochromia 1+ Treating underlying causes of iron deficiency. Smoking should be quit as it contains nicotine and caffeine responsible for less absorption of iron. Last medically reviewed on December 20, 2019. (B) Cation-exchange HPLC analysis of patient's blood sample showed two . Our website services, content, and products are for informational purposes only. This decrease in redness is due to a disproportionate reduction of red . . It can detect parasites like malaria parasites as well. Do complete blood count, red blood cell indices, reticulocyte count, and peripheral smear. Anemia is so severe that transfusions are often necessary; however, they are of only temporary value and lead to excessive iron in the tissues once the transfused red cells break down. American Society of Hematology: "Blood Basics. Destruction of red cells at a rate substantially greater than normal, if not compensated for by accelerated red cell production, causes hemolytic anemia. 5 Immunological mechanisms. Polychromasia ( , many) 78 . These measurements were more sensitive than the conventional red cell indices for detecting blood donors with a low transferrin saturation. Elliptocytes and Ovalocytes: are interchangeable terms used to indicate ovalshaped erythrocytes. Differential diagnosis and management of iron deficiency anemia. Red blood cells are formed in various organs in various stage of life. The symptoms vary depending upon the underlying disease causing this condition. Many conditions can cause RBC destruction and lead to hemolytic anemia. Overloading the body with iron can be dangerous because excess iron accumulation can damage your liver and cause other complications. In this article, well discuss what polychromasia is, what blood disorders can cause it, and what the symptoms might be for those underlying conditions. RBC populations with a normal MCHC value are normochromic. In some cases, radiation therapy can cause changes in the way blood cells look. Polychromasia means multi coloured red blood cells in your blood. Mixing Benadryl and alcohol can be dangerous ! In this condition most of the red cells in a sample of fresh blood look normally shapeddiscoidaluntil deprived of oxygen, when the characteristic sickle- or crescent-shaped forms with threadlike extremities appear. As a result, iron deficiency anemia may leave you tired and short of breath. There are normally two pairs of -genes, and the severity of the anemia is determined by the number deleted. 1). Such cells are mechanically fragile and readily swell up and burst in dilute salt solution. Hemoglobin H crystals are associated with Hemoglobin H disease. As the name implies, iron deficiency anemia is due to insufficient iron. Hypochromic anemia can lead to pica (a condition in which the patient feels craving or the non-food items like paper, paint, dirt etc. Increased red cell destruction is recognized by demonstrating increased quantities of the pigmentary products of their destruction, such as bilirubin and urobilinogen, in the blood plasma, urine, and feces and by evidence of accelerated erythropoiesis, such as an increase in the number of young cells (reticulocytes) in the blood. Blood Loss. At that time, theyll be able to detect polychromasia on a blood smear if its present. Subscribe to our e-mail newsletter to receive updates. With this test RBC size, morphology and indices can be examined. When you have polychromasia, its important to find the underlying cause so that you can receive treatment right away. 17. Polychromasia. cardiovascular disease: Shock due to inadequate blood volume, Learn about sickle cell anemia and how a tiny microfluidic device can help analyze the behaviour of blood from sickle cell patients, Diseases related to platelets and coagulation proteins, 17 Questions About Health and Wellness Answered, 44 Questions from Britannicas Most Popular Health and Medicine Quizzes, Cardiovascular & Circulatory System Diseases. Answer (1 of 4): Polychromasia = Your red blood cells (rbcs) show up with different shades of red, or paleness on a blood smear under microscopic examination (poly = love of many colors). Hypochromia means that the red blood cells have less color than normal when examined under a microscope. This usually occurs when there is not enough of the pigment that carries oxygen ( hemoglobin) in the red blood cells. These types of cancers are likely to show polychromasia during blood testing. The deficiency of iron-containing enzymes in the tissues, if sufficiently great, results in a smooth tongue; brittle, flattened fingernails; and lustreless hair. . Prolonged breastfeeding, excessive amounts of cows' milk and strict vegan diets may lead to iron deficiency . Paroxysmal nocturnal hemoglobinuria (PNH). ", Patient: "Bone Marrow and Bone Marrow Failure.". What does Polychromasia 2+ mean? When you don't have enough red blood cells for your organs and tissues to get as much oxygen as they need, you develop anemia. Children aged 6 months to 6 years are considered anemic at Hb levels less than 11 g/dL, and children aged 6-14 years are considered anemic when Hb levels are less than 12 g/dL. Marked anisocytosis, or variation in RBC size, Acanthocytes resemble spurs on cowboy boots, but they have uneven projections (spicules), Acanthocytes are the rbc's seen with projections of spicules around the surface, A single acanthocyte can be observed in the middle of this slide, This slide contains numerous acanthocytes, This slide contains numerous elliptical shaped elliptocytes, An elliptocyte and a couple of ovalocytes. Before we start with the abnormal morphologies, lets talk about normal morphology of Red Blood Cells. Trapping of the red cells by the spleen is thought to depend on the fact that, when brought into contact with reticuloendothelial cells, red cells coated with incomplete (nonhemolytic) antibody adhere, become spherical, are ingested (phagocytosed), and break down. Its an indication of red blood cells being released prematurely from bone marrow during formation. Hypochromia is often seen with microcytosis and thus have similar . Target Cells (Codocytes): erythrocytes that are thinner than normal which show a peripheral rim of hemoglobin with a dark central hemoglobin-containing area. Polychromasia can be a sign of a serious blood disorder, such as hemolytic anemia or blood cancer. Anisopoikilocytosis refers to a condition characterized by blood with varying shapes and sizes of red blood cells (RBCs). . Treatment options may include: If youve been diagnosed with any of the conditions that can cause polychromasia, talk to your doctor about the safest, most effective treatment options for you. Tachycardia occurs and the heart beat increases up to 100 beats per minute. Certain patients are susceptible to oxidant drugs such as antimalarial compounds mentioned above. The full effect of the deficiency is rarely observed in females because the gene is sex-linked (i.e., carried on the X chromosome), and only rarely do both X chromosomes carry the abnormal gene. It is important to rule out the cause of polychromasia before starting any treatment. This may occur in association with the presence of certain diseases, but it is often seen without other illness. In thalassemia it is thought that a primary genetic mutation results in reduction in the rate at which -, -, or -chains are manufactured, the chains being otherwise normal. The condition is defined as a mean corpuscular volume of less than 80 m 3 (80 . Red cells are examined in the lab under a microscope. Microcytic anemia is defined as the presence of small, often hypochromic, red blood cells in a peripheral blood smear and is usually characterized by a low mean corpuscular volume (MCV) (less than 83 micron) 2. Young RBC having nucleic acid RNA in their cytoplasm appear bluish gray or purple coloured. As we have already established, the word Hypochromasia means that the red blood cells lack their red coloring and for this reason, they are pale in color. Dr. Michael Dugan answered. It is usually seen in anemia and other blood disorders. Initially, iron deficiency anemia can be so mild that it goes unnoticed. Sometimes it can lead to a diagnosis of anisocytosis. For example, iron deficiency is the most common cause of microcytic anemia. This may lead to polychromasia when your blood is retested. With this disease, RBC turnover is most affected by hemolytic anemia. (n.d.). Polychromatophilia (polychromasia) refers to an increase in the number of younger RBCs (retculocytes) with incomplete hemoglobinizaton. Anemia signs and symptoms vary depending on the cause of your anemia. They also carry carbon dioxide from your body back to your lungs so that it can be exhaled during breathing. The most common causes of megaloblastic, macrocytic anemia are deficiency or defective utilization of vitamin B12 or folate. The four most common RBC inclusions are Howell-Jolly bodies, Pappenheimer bodies, Heinz bodies and basophilic stippling. Once in the body, it is retained and used over and over again, only minimal amounts being lost through shedding of cells from the skin and the exposed membranes and, in the female, through normal menstruation. So see your doctor for a diagnosis rather than taking iron supplements on your own. Macrocytosis: abnormally large erythrocytes (i.e., less than 8 in diameter). These findings are used in conjunction with other elements of your blood count to classify anemia and identify possible causes. Hemoglobin SC crystals are composed of hemoglobin S and hemoglobin C, and they resembled a, All cell lines are affected: Red blood cells, White blood cells, Platelets. Sideroblastic anemia, characterized by the presence in the bone marrow of nucleated red blood cells, the nucleus of which is surrounded by a ring of iron granules (ringed sideroblasts) and by a proportion of small, pale red cells in the blood, is of unknown cause and difficult to treat. Hemoglobin is composed of a porphyrin compound (heme) and globin. 1 doctor answer 1 doctor weighed in. It is an indication of various diseases. Polychromasia shows up when your red blood cells appear blue or gray when treated with the dye. A rare immature myeloid cell was seen on scanning (Figure 7). 4 Cell biology. The size of the red cell is measured separately from the chromasia. This deficiency results in destruction of red cells (hemolysis). The crystals may intracellular or extra-cellular. This condition is when your red blood cells are destroyed faster than they can be replaced. Polychromasia refers to macrocytic (large) red blood cells with a bluish tinge, due to residual RNA. numerically (plus) from 1+ to 4+, others used descrip-tive terms, such as slight (few), moderate, or marked, and/or 'rare' or 'occasional'. Hemolytic anemia can be inherited, meaning you had it when you were born, or acquired, which means you developed it later in life. They are formed from stem cells undergoing development in various stages. Some possible treatment approaches are. 3. . For this test a few drops of your blood are taken on a glass slide. In these cases there is increased oxygen affinity, limiting proper delivery of oxygen to tissues and thereby stimulating the bone marrow to increase red cell production. Sideroblastic Anaemia. Prescribed medicines can also be the cause of hypochromic anemia. Study with Quizlet and memorize flashcards containing terms like 1. Red blood cells (RBCs) are formed in your bone marrow. There are no symptoms directly associated with polychromasia. The relative deficiency of one pair of chains and the resultant imbalance of chain pairs result in ineffective production of red blood cells, deficient hemoglobin production, microcytosis (small cells), and destruction of red cells (hemolysis). Ferrum met and ferrum phos are the bone marrow stimulating agents which produce the healthy Red blood cells. Thalassemia major Cancer in the bone marrow. The cause of hypochromia should be evaluated by your health care provider. The red cells in this condition are unusually flat with central staining areas and for this reason have been called target cells. Your doctor will let you know the correct dose for you. These cells are likely reticulocytes, which are immature non-nucleated red cells which have only just extruded their nuclei. Bain BJ. If the cytoplasm contains RNA or nucleic acid it stains with bluish grey colour. Everything you should know about Microcytic anemia, Pancytopenia: Causes, symptoms, complications and treatments, HBCBC Test | Hemogram | Complete blood count, Anemia still a rising concern in the world, Renal function test (RFT) or Kidney function test (KFT). It is characterized by the presence of red cells that appear small, stain densely for hemoglobin, and look nearly spherical. The only treatment required is oral administration of iron salts in some palatable form, such as ferrous sulfate. But as the body becomes more deficient in iron and anemia worsens, the signs and symptoms intensify. These types of conditions can result in increased blood loss and the destruction of RBCs, which in turn can increase RBC production. You can enhance your bodys absorption of iron by drinking citrus juice or eating other foods rich in vitamin C at the same time that you eat high-iron foods. Sore mouth shows the severity of disease. Normal adult hemoglobin (Hb A) consists of globin containing two pairs of polypeptide chains, alpha () and beta (). Which diseases cause polychromasia? . . Hypochromia is defined as low mean corpuscular hemoglobin concentration (MCHC) in the setting of normal hemoglobin . Red blood cells will also be small (microcytic), leading to substantial overlap with the category of microcytic anemia. In the mild form of the disease, thalassemia minor, there is usually only slight or no anemia, and life expectancy is normal. In th. Hemolytic anemia is a type of anemia that occurs when your body cant produce RBCs as quickly as theyre being destroyed. google_ad_client: "ca-pub-9759235379140764", Scanning electron microscopy 80 . 2 Modern medicine: foundations, achievements, and limitations. Increased hypochromia indicates iron deficiency anemia, which occurs . 1. (1) Normocyte - 6~8 - MCV 80~100fL - - - - - (2) Microcyte - 6 - MCV 80fL - - - - . There, the lab technician looks at it under a microscope. These cells contain haemoglobin. Anisochromic: indicates the presence of both normochromic and Hypochromic. Normally, red blood cells should be about the same size. Normal red blood cell cytoplasm typically does not contain any debris, granules, or structures. Another variety of G-6-PD deficiency is especially frequent in persons of Mediterranean descent. Codocytes, or Target Cells, resemble targets, a bullseye or Mexican hats. Then special stains are used for colouring them. Iron deficiency is common in infancy and childhood because demands are great for the ever-expanding pool of circulating hemoglobin in the growing body, and in pregnancy when the fetus must be supplied with iron. Hypochromia - Symptoms, Causes, Treatment, This website is an online medical resource dedicated to offering detailed and current literature on diseases, remedies, health care, drugs and medical conditions. 28. Certain blood cancers, such as leukemia, start at the bone marrow and can greatly influence RBC production. Serum iron and serum ferritin are other chemistry tests used to rule out iron-deficiency anemia since symptoms are similar. While the many complications of the disease can be treated and pain relieved, there is no treatment to reverse or prevent the actual sickling process. Red cell morphology: Ovalocytes are red blood cells which have lost their normal biconcave shape. When we look at a normal red cell in a blood smear, the amount of hemoglobin in a normal red cell is normal, so the red cell looks Red orange in color. Mild iron deficiency anemia usually doesnt cause complications. Antibodies to the substances alpha- and beta-isoagglutinin, which occur naturally in the blood, destroy the donor red cells when incompatible blood is given by transfusion. Iron deficiency anemia develops when the diet lacks iron, the gastrointestinal tract fails to absorb dietary iron, or the amount of iron lost by the body is abnormally high 2. Premature RBCs are called reticulocytes. Polychromasia is a lavender-bluish color to RBC's due to RNA retained in larger, immature cells (macrocytes). Normal RBC look pink or orange or no colour. Specializes in Hematology. Polychromasia ; Nucleated RBCs ; Possible hypochromia and microcytosis ; Codocytes (target cells) Basophilic stippling ; Reticulocyte count: Normal: May be slightly increased: Slightly increased (<5%) Mildly increased (5 - 10%) Mildly increased: Hb electrophoresis: 8 Sexually transmitted diseases and sexual health. In the body they break up when deprived of free access to plasma glucose. Constipation can occur due to decreased circulation. All rights reserved to Healthcaretip.com | Powered by Blogger. For example, common cell colors can range from blue to deep purple, and more. Polychromasia is the presentation of multicolored red blood cells in a blood smear test. At least 8 percent of black Americans carry the sickle cell trait. The abnormality is aggravated by a tendency for the cells to remain longer than usual in the spleen because of their spheroidal shape. Peripheral smear shows target cells, teardrop RBCs, polychromasia, moderate anisopoikilocytosis, and basophilic stippling. Lead poisoning is another leading cause of hypochromic anemia. Severe iron deficiency. WebMD does not provide medical advice, diagnosis or treatment. Cows milk isnt a good source of iron for babies and isnt recommended for infants under 1 year. They are present along with normal or abnormal mature RBCs. Red blood cells constitutes major part of your blood volume. Polychromasia occurs on a lab test when some of your red blood cells show up as bluish-gray when they are stained with a particular type of dye. Hypochromia means that the red blood cells have less color than normal when examined under a microscope. . Some conditions that can cause polychromasia include:. Anisocytosis is the medical term for having red blood cells (RBCs) that are unequal in size. Hypochromic microcytic anemias, characterized by the presence in the circulating blood of red cells that are smaller than normal and poorly filled with hemoglobin, fall into two main categories. To treat iron deficiency anemia, your doctor may recommend that you take iron supplements. With acquired hemolytic anemia, your body produces normal red blood cells, but they are destroyed too quickly. Codocytes, or target cells, lack a ring of hemoglobin in the middle ring, Dacrocytes are a result of "squeezing" through the spleen, Echinocytes are similar to acanthocytes, however, the spicules are smaller and even, Echinocyte formation may be crenated rbc's due to the EDTA anticoagulant or from the blood sitting for too long, or it may be pathological as seen in this slide, DIC with microangiopathic hemolytic anemia with acanthocytes, schistocytes and spherocytes, Warm autoimmune hemolytic anemia with spherocytes, Thrombotic Thrombocytopenic Purpura (TTP) seen here with spherocytes, schistocytes, polychromatic cells (bluish reticulocytes). Hypochromasia is usually classified in several levels which are coded as 1+, 2+ and 3+. A blood smear tells your doctor about the different types of cells and the amounts of each that are in your blood., A peripheral blood smear tells how many red blood cells, white blood cells, and platelets are in your blood. Why did you have the blood checked in the first place? Hypochromia Symptoms: The most common symptoms of hypochromic anemia are as follows: Clinical depression is often seen with this condition. They are exemplified by diseases in which the cell membrane is weakened, cell metabolism is defective, or hemoglobin is abnormal. In addition to a decreased Hgb and Hct values, what other CBC parameters may be anticipated? Hypochromic microcytic anemias, characterized by the presence in the circulating blood of red cells that are smaller than normal and poorly filled with hemoglobin, fall into two main categories. Certain chemical agents destroy red cells whenever sufficient amounts are given (e.g., phenylhydrazine); others are harmful only to persons whose red cells are sensitive to the action of the agent. Polychromasia is usually a sign of bone marrow stress as well as immature red blood cells . These immature cells are called reticulocytes.. Anisochromic:indicates the presence of both normochromic and Hypochromic, Anisochromic (Normochromic plus Hypochromic). (2017). A deficiency in iron can be caused by massive blood loss or not being able to eat iron-rich foods. 18. Howell-Jelly: are intracellular particles which are smooth, round remnants of nuclear chromatin (DNA. If you arent consuming enough iron, or if youre losing too much iron, your body cant produce enough hemoglobin, and iron deficiency anemia will eventually develop. A hormone produced by kidney called erythropoietin is needed for this process to get stimulated. The thalassemias are another group of inherited disorders in which one or more of the polypeptide chains of globin are synthesized defectively. If . They may be significant if your Hemoglobin is low ( Anemia ). It simply means on peripheral blood smear you have RBCs or many colours. Heavy periods in women and gastric bleeding due to ulcers can also cause hypochromic anemia. They may include: (adsbygoogle = window.adsbygoogle || []).push({}); (adsbygoogle = window.adsbygoogle || []).push({ Cells that have too much RNA are immature because they were released too soon from your bone marrow.. DIC (Disseminated intravascular coagulation), Klebsiella characteristics on MacConkey Agar, Clinical Case Leukocyte Vacoulation Bacterial Infection, Segmented neutrophilic granulocyte during degradation, Creatinine Phosphate Kinase (CPK) and CK-MB Overview.